Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
A0PJY2
UPID:
FEZF1_HUMAN
Alternative names:
Zinc finger protein 312B
Alternative UPACC:
A0PJY2; A0PJY3; A4D0W3; B4DUP9; B7ZM98
Background:
Fez family zinc finger protein 1, also known as Zinc finger protein 312B, plays a crucial role in the development of the nervous system. It is involved in axonal projection, termination of olfactory sensory neurons, and patterning of the diencephalon. Its expression is vital for the regulation of olfactory bulb development and interneuron migration.
Therapeutic significance:
The protein is linked to Hypogonadotropic hypogonadism 22 with or without anosmia, a condition affecting sexual maturation and olfactory function. Understanding the role of Fez family zinc finger protein 1 could open doors to potential therapeutic strategies for this disorder.