Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Several key aspects differentiate our library:
partner
Reaxense
upacc
A1L3X0
UPID:
ELOV7_HUMAN
Alternative names:
3-keto acyl-CoA synthase ELOVL7; ELOVL fatty acid elongase 7; Very long chain 3-ketoacyl-CoA synthase 7; Very long chain 3-oxoacyl-CoA synthase 7
Alternative UPACC:
A1L3X0; Q589T3; Q9H5D0; Q9NT66
Background:
Elongation of very long chain fatty acids protein 7 (ELOVL7) plays a pivotal role in the biosynthesis of long-chain fatty acids, catalyzing the first and rate-limiting step in the elongation cycle. This enzyme exhibits a preference for C18 acyl-CoAs, particularly C18:3(n-3) and C18:3(n-6) substrates, and is crucial for producing saturated and polyunsaturated very long-chain fatty acids (VLCFAs). These VLCFAs serve as precursors for membrane lipids and lipid mediators, underscoring the enzyme's importance in cellular processes.
Therapeutic significance:
Understanding the role of Elongation of very long chain fatty acids protein 7 could open doors to potential therapeutic strategies.