Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The method includes detailed molecular simulations of the catalytic and allosteric binding pockets, along with ensemble virtual screening that considers their conformational flexibility. In the design of modulators, structural changes induced by reaction intermediates are taken into account to enhance activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
A4D2B0
UPID:
MBLC1_HUMAN
Alternative names:
Endoribonuclease MBLAC1
Alternative UPACC:
A4D2B0; Q8N5X8
Background:
Metallo-beta-lactamase domain-containing protein 1 (MBLAC1), also known as Endoribonuclease MBLAC1, plays a pivotal role in the cell cycle's S-phase. It specifically catalyzes the hydrolysis of histone-coding pre-mRNA 3'-end, essential for S-phase progression. MBLAC1's activity involves cleaving histone pre-mRNA at both major and minor cleavage sites, following specific sequences downstream of the stem-loop, a process critical for histone pre-mRNA processing.
Therapeutic significance:
Understanding the role of Metallo-beta-lactamase domain-containing protein 1 could open doors to potential therapeutic strategies. Its precise function in histone pre-mRNA processing during cell cycle progression highlights its potential as a target for interventions in diseases where cell cycle regulation is disrupted.