AI-ACCELERATED DRUG DISCOVERY

Focused On-demand Library for Outer dynein arm-docking complex subunit 3

Available from Reaxense
Predicted by Alphafold

Focused On-demand Libraries - Reaxense Collaboration

Explore the Potential with AI-Driven Innovation

Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.

The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.

The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.

Our high-tech, dedicated method is applied to construct targeted libraries.

 Fig. 1. The sreening workflow of Receptor.AI

Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.

Key features that set our library apart include:

  • The Receptor.AI platform integrates extensive information about the target protein, such as historical experiments, academic research, known ligands, and structural insights, thereby increasing the likelihood of identifying highly relevant compounds.
  • The platform’s sophisticated molecular simulations are designed to discover potential binding sites, ensuring that our focused library is optimal for the discovery of allosteric inhibitors and binders for cryptic pockets.
  • With over 50 customisable AI models, verified through extensive testing in commercial drug discovery and research, Receptor.AI is efficient, reliable, and precise. These models are essential in the production of our focused libraries.
  • Receptor.AI not only produces focused libraries but also provides full services and solutions at every stage of preclinical drug discovery, with a success-based pricing structure that aligns our interests with the success of your project.

partner

Reaxense

upacc

A5D8V7

UPID:

ODAD3_HUMAN

Alternative names:

Coiled-coil domain-containing protein 151

Alternative UPACC:

A5D8V7; B4DXT0; Q96CG5

Background:

Outer dynein arm-docking complex subunit 3, also known as Coiled-coil domain-containing protein 151, plays a crucial role in the assembly and attachment of outer dynein arms on ciliary microtubules. This process is vital for the proper function of motile cilia, which are essential for fluid movement across cell surfaces.

Therapeutic significance:

Mutations in this protein lead to Primary Ciliary Dyskinesia, a condition marked by chronic respiratory infections and potentially situs inversus. Understanding the role of Outer dynein arm-docking complex subunit 3 could open doors to potential therapeutic strategies for this genetic disorder.

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