Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
A5D8V7
UPID:
ODAD3_HUMAN
Alternative names:
Coiled-coil domain-containing protein 151
Alternative UPACC:
A5D8V7; B4DXT0; Q96CG5
Background:
Outer dynein arm-docking complex subunit 3, also known as Coiled-coil domain-containing protein 151, plays a crucial role in the assembly and attachment of outer dynein arms on ciliary microtubules. This process is vital for the proper function of motile cilia, which are essential for fluid movement across cell surfaces.
Therapeutic significance:
Mutations in this protein lead to Primary Ciliary Dyskinesia, a condition marked by chronic respiratory infections and potentially situs inversus. Understanding the role of Outer dynein arm-docking complex subunit 3 could open doors to potential therapeutic strategies for this genetic disorder.