Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
A5D8W1
UPID:
CFA69_HUMAN
Alternative names:
-
Alternative UPACC:
A5D8W1; A3KMP9; B4DYW6; B4DZP7; B9EIM7; Q6V705; Q8IY89; Q9H7C2
Background:
Cilia- and flagella-associated protein 69 plays a pivotal role in the assembly and stability of sperm flagella, essential for proper sperm morphology and motility. It also contributes to the olfactory transduction pathways, enhancing the speed of odor response activation and termination.
Therapeutic significance:
The protein's malfunction is linked to Spermatogenic failure 24, a genetic disorder impairing fertility due to defects in spermatogenesis. Understanding the role of Cilia- and flagella-associated protein 69 could open doors to potential therapeutic strategies for treating infertility.