Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
A6NCK2
UPID:
TR43B_HUMAN
Alternative names:
-
Alternative UPACC:
A6NCK2
Background:
Tripartite motif-containing protein 43B, encoded by the gene symbol A6NCK2, is a member of the TRIM protein family. These proteins are known for their roles in various cellular processes, including cell proliferation, differentiation, and apoptosis. The specific functions of Tripartite motif-containing protein 43B, however, remain to be fully elucidated.
Therapeutic significance:
Understanding the role of Tripartite motif-containing protein 43B could open doors to potential therapeutic strategies. Its involvement in fundamental cellular processes suggests that it could be a target for drug discovery efforts aimed at treating a wide range of diseases.