Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We employ our advanced, specialised process to create targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes comprehensive molecular simulations of the catalytic and allosteric binding pockets and the ensemble virtual screening accounting for their conformational mobility. In the case of designing modulators, the structural changes induced by reaction intermediates are taken into account to leverage activity and selectivity.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
A6NNW6
UPID:
ENO4_HUMAN
Alternative names:
2-phospho-D-glycerate hydro-lyase
Alternative UPACC:
A6NNW6; A0A087WZY6; A6NI74; B8ZZN9; J3KNX1
Background:
Enolase 4, also known as 2-phospho-D-glycerate hydro-lyase, plays a crucial role in cellular processes, particularly in sperm motility and function. This protein's unique enzymatic activity is essential for energy production and cellular homeostasis, making it a key player in reproductive biology.
Therapeutic significance:
Understanding the role of Enolase 4 could open doors to potential therapeutic strategies. Its pivotal function in sperm motility and function highlights its importance in reproductive health, suggesting that targeting Enolase 4 could lead to novel treatments for male infertility.