Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
A8MYU2
UPID:
KCNU1_HUMAN
Alternative names:
Calcium-activated potassium channel subunit alpha-3; Calcium-activated potassium channel, subfamily M subunit alpha-3; KCa5; Slowpoke homolog 3
Alternative UPACC:
A8MYU2
Background:
Potassium channel subfamily U member 1, also known as KCa5, plays a pivotal role in male fertility. This testis-specific potassium channel is uniquely activated by intracellular pH and membrane voltage, facilitating the export of K(+). Unlike KCNMA1/SLO1, it does not respond to Ca(2+) or Mg(2+). Its function is crucial for sperm osmoregulation, ensuring sperm acquire normal morphology and motility under osmotic stress.
Therapeutic significance:
Spermatogenic failure 79, a male infertility disorder characterized by asthenoteratozoospermia, is linked to mutations affecting this protein. Understanding the role of Potassium channel subfamily U member 1 could lead to novel treatments for this condition.