Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
D3W0D1
UPID:
KLRF2_HUMAN
Alternative names:
Activating coreceptor NKp65
Alternative UPACC:
D3W0D1
Background:
Killer cell lectin-like receptor subfamily F member 2, also known as Activating coreceptor NKp65, is a C-type lectin-like receptor. It plays a crucial role in natural killer cell mediated cytotoxicity and cytokine secretion in keratinocytes through its interaction with CLEC2A. This interaction is vital for the immune response and maintaining the integrity of the skin barrier.
Therapeutic significance:
Understanding the role of Killer cell lectin-like receptor subfamily F member 2 could open doors to potential therapeutic strategies. Its involvement in immune response mechanisms positions it as a key target for developing novel treatments aimed at enhancing natural killer cell functions.