Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
I1YAP6
UPID:
TRI77_HUMAN
Alternative names:
-
Alternative UPACC:
I1YAP6
Background:
Tripartite motif-containing protein 77 (TRIM77) is a member of the TRIM protein family, known for its roles in cellular processes such as intracellular signaling and development. Despite its identification, the specific functions of TRIM77 in cellular mechanisms remain to be fully elucidated. Its structure, characterized by the tripartite motif, suggests a potential for diverse biological interactions and functions.
Therapeutic significance:
Understanding the role of Tripartite motif-containing protein 77 could open doors to potential therapeutic strategies. The exploration of TRIM77's functions and mechanisms may reveal novel targets for drug discovery, offering new avenues for treating diseases with unknown pathologies.