Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The procedure entails thorough molecular simulations of the catalytic and allosteric binding pockets, accompanied by ensemble virtual screening that factors in their conformational flexibility. When developing modulators, the structural modifications brought about by reaction intermediates are factored in to optimize activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
O00204
UPID:
ST2B1_HUMAN
Alternative names:
Alcohol sulfotransferase; Hydroxysteroid sulfotransferase 2; Sulfotransferase family 2B member 1; Sulfotransferase family cytosolic 2B member 1
Alternative UPACC:
O00204; O00205; O75814
Background:
Sulfotransferase 2B1, also known as Hydroxysteroid sulfotransferase 2, plays a pivotal role in the sulfation of cholesterol and steroids like pregnenolone and DHEA. This enzyme is crucial for cholesterol metabolism and the regulation of epidermal proliferation and differentiation, highlighting its significance in skin health.
Therapeutic significance:
Linked to Ichthyosis, congenital, autosomal recessive 14, Sulfotransferase 2B1's dysfunction underscores its potential as a therapeutic target. Understanding the role of Sulfotransferase 2B1 could open doors to potential therapeutic strategies for skin disorders, emphasizing the need for innovative treatments.