Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
O00264
UPID:
PGRC1_HUMAN
Alternative names:
Dap1; IZA
Alternative UPACC:
O00264; B7Z1L3; Q9UGJ9
Background:
Membrane-associated progesterone receptor component 1 (MAPR1), also known as Dap1 and IZA, plays a pivotal role in various cellular processes. It is a part of a progesterone-binding protein complex, essential for progesterone binding, and is involved in heme homeostasis and interactions with cytochrome P450 enzymes (CYPs). MAPR1 is crucial for maintaining uterine structure and female reproductive health, acting as an intracellular heme chaperone and regulating heme synthesis through interactions with FECH.
Therapeutic significance:
Understanding the role of Membrane-associated progesterone receptor component 1 could open doors to potential therapeutic strategies.