Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
O00410
UPID:
IPO5_HUMAN
Alternative names:
Importin subunit beta-3; Karyopherin beta-3; Ran-binding protein 5
Alternative UPACC:
O00410; B4DZA0; O15257; Q5T578; Q86XC7
Background:
Importin-5, also known as Importin subunit beta-3, Karyopherin beta-3, and Ran-binding protein 5, plays a crucial role in nuclear protein import. It acts as a nuclear transport receptor, mediating the docking of importin/substrate complexes to the nuclear pore complex (NPC) and facilitating their Ran-dependent translocation. Importin-5 is pivotal in the nuclear import of ribosomal proteins RPL23A, RPS7, RPL5, and histones H2A, H2B, H3, and H4. Additionally, it binds to CPEB3, mediating its nuclear import post-neuronal stimulation, and plays a role in HIV-1 infection by aiding the nuclear import of HIV-1 Rev.
Therapeutic significance:
Understanding the role of Importin-5 could open doors to potential therapeutic strategies.