Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We employ our advanced, specialised process to create targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The procedure entails thorough molecular simulations of the catalytic and allosteric binding pockets, accompanied by ensemble virtual screening that factors in their conformational flexibility. When developing modulators, the structural modifications brought about by reaction intermediates are factored in to optimize activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
O00442
UPID:
RTCA_HUMAN
Alternative names:
RNA terminal phosphate cyclase domain-containing protein 1
Alternative UPACC:
O00442; Q5VVL5; Q5VVL6; Q96E99
Background:
RNA 3'-terminal phosphate cyclase plays a crucial role in RNA processing, catalyzing the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at RNA's end. This enzyme operates through a three-step mechanism involving adenylation, transfer of adenylate, and the production of a cyclic end product, highlighting its intricate function in cellular RNA dynamics.
Therapeutic significance:
Understanding the role of RNA 3'-terminal phosphate cyclase could open doors to potential therapeutic strategies. Its involvement in RNA processing suggests a foundational role in cellular biology, offering a promising avenue for exploring novel drug targets.