Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The procedure entails thorough molecular simulations of the catalytic and allosteric binding pockets, accompanied by ensemble virtual screening that factors in their conformational flexibility. When developing modulators, the structural modifications brought about by reaction intermediates are factored in to optimize activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
O00744
UPID:
WN10B_HUMAN
Alternative names:
Protein Wnt-12
Alternative UPACC:
O00744; B2R7A5; O00747; Q4VAJ4; Q4VAJ5; Q8WZ97
Background:
Protein Wnt-10b, also known as Protein Wnt-12, is a pivotal member of the Wnt ligand gene family. It plays a crucial role in activating the canonical Wnt/beta-catenin signaling pathway, which is essential for regulating stemness, pluripotency, and cell fate decisions. This protein's influence extends across various biological systems, including the immune system, mammary gland, adipose tissue, bone, and skin.
Therapeutic significance:
Protein Wnt-10b's involvement in Split-hand/foot malformation 6 and Tooth agenesis, selective, 8, underscores its potential as a target for therapeutic intervention. Understanding the role of Protein Wnt-10b could open doors to potential therapeutic strategies for these conditions.