Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
O14657
UPID:
TOR1B_HUMAN
Alternative names:
Torsin ATPase-1B; Torsin family 1 member B
Alternative UPACC:
O14657
Background:
Torsin-1B, also known as Torsin ATPase-1B and Torsin family 1 member B, plays a crucial role in cellular processes. It functions as a molecular chaperone, aiding in the proper folding of secreted and/or membrane proteins. Additionally, Torsin-1B is involved in maintaining the integrity of the nuclear envelope and endoplasmic reticulum in non-neural cells, potentially working alongside TOR1A in non-neural tissues.
Therapeutic significance:
Understanding the role of Torsin-1B could open doors to potential therapeutic strategies.