Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We employ our advanced, specialised process to create targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes comprehensive molecular simulations of the catalytic and allosteric binding pockets and the ensemble virtual screening accounting for their conformational mobility. In the case of designing modulators, the structural changes induced by reaction intermediates are taken into account to leverage activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
O14980
UPID:
XPO1_HUMAN
Alternative names:
Chromosome region maintenance 1 protein homolog
Alternative UPACC:
O14980; A6NL14; A8K1K5; D6W5E2; Q63HP8; Q68CP3; Q99433
Background:
Exportin-1, also known as Chromosome region maintenance 1 protein homolog, plays a crucial role in the nuclear export of proteins and RNAs with a leucine-rich nuclear export signal. It operates in conjunction with RANBP3 and RAN GTPase, facilitating the transport of cargos through the nuclear pore complex. This protein is also pivotal in the transport of U3 snoRNA from Cajal bodies to nucleoli and assists in the export of viral RNAs, including those from HIV-1 and HTLV-1.
Therapeutic significance:
Understanding the role of Exportin-1 could open doors to potential therapeutic strategies.