Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We use our state-of-the-art dedicated workflow for designing focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The method includes detailed molecular simulations of the catalytic and allosteric binding pockets, along with ensemble virtual screening that considers their conformational flexibility. In the design of modulators, structural changes induced by reaction intermediates are taken into account to enhance activity and selectivity.
Several key aspects differentiate our library:
partner
Reaxense
upacc
O14981
UPID:
BTAF1_HUMAN
Alternative names:
ATP-dependent helicase BTAF1; B-TFIID transcription factor-associated 170 kDa subunit; TAF(II)170; TBP-associated factor 172
Alternative UPACC:
O14981; B4E0W6; O43578
Background:
TATA-binding protein-associated factor 172, also known as ATP-dependent helicase BTAF1, plays a crucial role in regulating transcription in association with TATA binding protein (TBP). It uniquely removes TBP from the TATA box in an ATP-dependent manner, highlighting its significance in the transcription initiation process. Alternative names include B-TFIID transcription factor-associated 170 kDa subunit, TAF(II)170, and TBP-associated factor 172.
Therapeutic significance:
Understanding the role of TATA-binding protein-associated factor 172 could open doors to potential therapeutic strategies. Its pivotal function in transcription regulation suggests that modulating its activity could influence gene expression patterns involved in various diseases.