Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes in-depth molecular simulations of both the catalytic and allosteric binding pockets, with ensemble virtual screening focusing on their conformational flexibility. For modulators, the process includes considering the structural shifts due to reaction intermediates to boost activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
O15121
UPID:
DEGS1_HUMAN
Alternative names:
Cell migration-inducing gene 15 protein; Degenerative spermatocyte homolog 1; Dihydroceramide desaturase-1; Membrane lipid desaturase; Retinol isomerase
Alternative UPACC:
O15121
Background:
Sphingolipid delta(4)-desaturase DES1, also known as dihydroceramide desaturase-1, plays a pivotal role in sphingolipid metabolism by converting D-erythro-sphinganine to D-erythro-sphingosine. This enzyme is also involved in the isomerization of retinols, indicating its diverse biological functions. Alternative names include Cell migration-inducing gene 15 protein and Retinol isomerase.
Therapeutic significance:
Leukodystrophy, hypomyelinating, 18, a severe neurological disorder, is linked to mutations in the gene encoding Sphingolipid delta(4)-desaturase DES1. Understanding the role of this protein could open doors to potential therapeutic strategies for this debilitating condition.