Focused On-demand Library for Actin-related protein 2/3 complex subunit 1B

Available from Reaxense
Predicted by Alphafold

Focused On-demand Libraries - Reaxense Collaboration

Explore the Potential with AI-Driven Innovation

Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.

We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.

The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.

Our high-tech, dedicated method is applied to construct targeted libraries.

 Fig. 1. The sreening workflow of Receptor.AI

Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.

Our library is unique due to several crucial aspects:

  • Receptor.AI compiles all relevant data on the target protein, such as past experimental results, literature findings, known ligands, and structural data, thereby enhancing the likelihood of focusing on the most significant compounds.
  • By utilizing advanced molecular simulations, the platform is adept at locating potential binding sites, rendering the compounds in the focused library well-suited for unearthing allosteric inhibitors and binders for hidden pockets.
  • The platform is supported by more than 50 highly specialized AI models, all of which have been rigorously tested and validated in diverse drug discovery and research programs. Its design emphasizes efficiency, reliability, and accuracy, crucial for producing focused libraries.
  • Receptor.AI extends beyond just creating focused libraries; it offers a complete spectrum of services and solutions during the preclinical drug discovery phase, with a success-dependent pricing strategy that reduces risk and fosters shared success in the project.







Alternative names:

Arp2/3 complex 41 kDa subunit; p41-ARC

Alternative UPACC:

O15143; Q9BU00


Actin-related protein 2/3 complex subunit 1B, also known as Arp2/3 complex 41 kDa subunit or p41-ARC, plays a pivotal role in cellular dynamics. It is a key component of the Arp2/3 complex, crucial for actin polymerization and the formation of branched actin networks in the cytoplasm. This process is essential for cell motility. Additionally, the Arp2/3 complex is involved in nuclear functions, including gene transcription and DNA repair, particularly through promoting homologous recombination repair in response to DNA damage.

Therapeutic significance:

The protein's involvement in Immunodeficiency 71 with inflammatory disease and congenital thrombocytopenia highlights its potential as a therapeutic target. Understanding the role of Actin-related protein 2/3 complex subunit 1B could open doors to potential therapeutic strategies for treating this genetic disorder and possibly other related inflammatory diseases.

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