Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
O15335
UPID:
CHAD_HUMAN
Alternative names:
Cartilage leucine-rich protein
Alternative UPACC:
O15335; A8K812; Q6GTU0; Q96RJ5
Background:
Chondroadherin, known as Cartilage leucine-rich protein, plays a crucial role in the musculoskeletal system. It promotes the attachment of chondrocytes, fibroblasts, and osteoblasts, primarily through the integrin alpha(2)beta(1). This interaction is pivotal for the regulation of chondrocyte growth and proliferation, suggesting its significant role in maintaining cartilage integrity and function.
Therapeutic significance:
Understanding the role of Chondroadherin could open doors to potential therapeutic strategies. Its involvement in the regulation of cell attachment and proliferation within cartilage presents a promising avenue for developing treatments aimed at musculoskeletal disorders, potentially improving patient outcomes in conditions affecting cartilage and bone.