Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The method includes detailed molecular simulations of the catalytic and allosteric binding pockets, along with ensemble virtual screening that considers their conformational flexibility. In the design of modulators, structural changes induced by reaction intermediates are taken into account to enhance activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
O15392
UPID:
BIRC5_HUMAN
Alternative names:
Apoptosis inhibitor 4; Apoptosis inhibitor survivin
Alternative UPACC:
O15392; A2SUH6; B2R4R1; Q2I3N8; Q4VGX0; Q53F61; Q5MGC6; Q6FHL2; Q75SP2; Q9P2W8
Background:
Baculoviral IAP repeat-containing protein 5, also known as Apoptosis inhibitor survivin, plays a pivotal role in cell cycle regulation by promoting cell proliferation and inhibiting apoptosis. It is a key component of the chromosome passage protein complex, essential for chromosome alignment and segregation during mitosis and cytokinesis. This protein also contributes to mitotic spindle formation and maintains mitochondrial integrity and function.
Therapeutic significance:
Understanding the role of Baculoviral IAP repeat-containing protein 5 could open doors to potential therapeutic strategies. Its involvement in cell proliferation and apoptosis prevention highlights its potential as a target in cancer therapy, where regulation of these processes is often disrupted.