Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
O15409
UPID:
FOXP2_HUMAN
Alternative names:
CAG repeat protein 44; Trinucleotide repeat-containing gene 10 protein
Alternative UPACC:
O15409; A0AUV6; A4D0U8; A6NNW4; B4DLD9; Q6ZND1; Q75MJ3; Q8IZE0; Q8N0W2; Q8N6B7; Q8N6B8; Q8NFQ1; Q8NFQ2; Q8NFQ3; Q8NFQ4; Q8TD74
Background:
Forkhead box protein P2, also known as CAG repeat protein 44 or Trinucleotide repeat-containing gene 10 protein, plays a pivotal role in the development of speech and language. It functions as a transcriptional repressor, crucial for lung epithelium differentiation, and contributes to neural, gastrointestinal, and cardiovascular tissue development. Additionally, it regulates synapse formation by controlling SRPX2 levels.
Therapeutic significance:
Linked to Speech-language disorder 1, Forkhead box protein P2's involvement in orofacial dyspraxia and language processing deficits highlights its potential as a target for therapeutic intervention. Understanding its role could pave the way for novel treatments for speech and language disorders.