Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes in-depth molecular simulations of both the catalytic and allosteric binding pockets, with ensemble virtual screening focusing on their conformational flexibility. For modulators, the process includes considering the structural shifts due to reaction intermediates to boost activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
O15488
UPID:
GLYG2_HUMAN
Alternative names:
-
Alternative UPACC:
O15488; B7WNN6; O15485; O15486; O15487; O15489; O15490
Background:
Glycogenin-2 plays a pivotal role in glycogen biosynthesis. It initiates the process by self-glucosylating, using an inter-subunit mechanism to form an oligosaccharide primer. This primer is then utilized by glycogen synthase to extend the glycogen molecule. Glycogenin-2's unique function underscores its importance in cellular energy storage and release mechanisms.
Therapeutic significance:
Understanding the role of Glycogenin-2 could open doors to potential therapeutic strategies. Its critical function in glycogen synthesis makes it a key target for exploring treatments related to energy metabolism disorders. The exploration of Glycogenin-2's mechanisms offers promising avenues for novel therapeutic interventions.