Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We employ our advanced, specialised process to create targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The procedure entails thorough molecular simulations of the catalytic and allosteric binding pockets, accompanied by ensemble virtual screening that factors in their conformational flexibility. When developing modulators, the structural modifications brought about by reaction intermediates are factored in to optimize activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
O15496
UPID:
PA2GX_HUMAN
Alternative names:
Group X secretory phospholipase A2; Phosphatidylcholine 2-acylhydrolase 10
Alternative UPACC:
O15496; Q14DU3; Q6NT23
Background:
Group 10 secretory phospholipase A2 (sPLA2), also known as Phosphatidylcholine 2-acylhydrolase 10, plays a pivotal role in lipid metabolism by hydrolyzing the sn-2 bond of phospholipids, favoring phosphatidylcholines and phosphatidylglycerols. It is involved in the remodeling of lipoproteins such as VLDL, LDL, and HDL, and regulates macrophage differentiation, contributing to the inflammatory response and tissue regeneration.
Therapeutic significance:
Understanding the role of Group 10 secretory phospholipase A2 could open doors to potential therapeutic strategies, particularly in managing lipid-related disorders, inflammation, and promoting tissue regeneration.