Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
O15539
UPID:
RGS5_HUMAN
Alternative names:
-
Alternative UPACC:
O15539; E9PMP5; Q53XA9; Q599J0
Background:
Regulator of G-protein signaling 5 (RGS5) plays a pivotal role in cellular signaling by increasing the GTPase activity of G protein alpha subunits, leading to their inactivation. This protein specifically interacts with G(i)-alpha and G(o)-alpha subunits, crucial for modulating signal transduction pathways.
Therapeutic significance:
Understanding the role of Regulator of G-protein signaling 5 could open doors to potential therapeutic strategies. Its involvement in critical signal transduction pathways suggests a potential for targeting in various pharmacological interventions.