Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
O15553
UPID:
MEFV_HUMAN
Alternative names:
Marenostrin
Alternative UPACC:
O15553; D3DUC0; F5H0Q3; Q3MJ84; Q96PN4; Q96PN5
Background:
Pyrin, also known as Marenostrin, plays a pivotal role in the regulation of innate immunity and inflammation in response to IFN-gamma. It orchestrates autophagic machinery, coordinating target recognition with the assembly of the autophagic apparatus and initiation of autophagy. Pyrin acts as an autophagy receptor for the degradation of inflammasome components, mitigating excessive inflammation, yet also promotes inflammation by triggering caspase-1 activation and cytokine production.
Therapeutic significance:
Pyrin's mutations are linked to Familial Mediterranean Fever (FMF), both autosomal recessive and dominant forms, and Pyrin-associated autoinflammatory disease (PAAND). These conditions are characterized by episodic fever, inflammation, and pain, with FMF also leading to renal failure. Understanding Pyrin's role could unveil new therapeutic strategies for these autoinflammatory disorders.