Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
O43143
UPID:
DHX15_HUMAN
Alternative names:
ATP-dependent RNA helicase #46; DEAH box protein 15; Splicing factor Prp43
Alternative UPACC:
O43143; Q9NQT7
Background:
ATP-dependent RNA helicase DHX15, also known as DEAH box protein 15 and Splicing factor Prp43, plays a pivotal role in mRNA processing and antiviral innate immunity. It is essential for the disassembly of spliceosomes post-mRNA maturation and cooperates with TFIP11 in intron turnover. DHX15 acts as a viral RNA sensor, activating MAVS-dependent signaling for interferon production and facilitating NLRP6 inflammasome activation in intestinal epithelial cells to combat enteric viruses.
Therapeutic significance:
Understanding the role of ATP-dependent RNA helicase DHX15 could open doors to potential therapeutic strategies.