Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
O43189
UPID:
PHF1_HUMAN
Alternative names:
Polycomb-like protein 1
Alternative UPACC:
O43189; B1AZX2; B1AZX3; O60929; Q5SU07; Q5SU08; Q96KM7
Background:
PHD finger protein 1, also known as Polycomb-like protein 1, plays a crucial role in chromatin remodeling and gene expression regulation. It specifically binds to histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex, influencing DNA damage response and double-strand breaks (DSBs) repair. The protein's interaction with H3K36me3, a marker for transcriptional activation, and its ability to regulate the PRC2 complex's activity, highlights its significance in epigenetic mechanisms.
Therapeutic significance:
Understanding the role of PHD finger protein 1 could open doors to potential therapeutic strategies, especially in the context of DNA repair mechanisms and epigenetic regulation.