Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
O43193
UPID:
MTLR_HUMAN
Alternative names:
G-protein coupled receptor 38
Alternative UPACC:
O43193
Background:
The Motilin receptor, encoded by the gene symbol O43193, is a pivotal G-protein coupled receptor 38, known for its exclusive role as a receptor for motilin. This protein is integral to gastrointestinal motility, mediating various physiological responses to motilin, a peptide hormone involved in the regulation of gastric and intestinal activity.
Therapeutic significance:
Understanding the role of the Motilin receptor could open doors to potential therapeutic strategies. Its unique position as a mediator of gastrointestinal motility highlights its potential as a target for the development of treatments aimed at disorders related to gastrointestinal movements and functions.