Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The method includes detailed molecular simulations of the catalytic and allosteric binding pockets, along with ensemble virtual screening that considers their conformational flexibility. In the design of modulators, structural changes induced by reaction intermediates are taken into account to enhance activity and selectivity.
Key features that set our library apart include:
partner
Reaxense
upacc
O43597
UPID:
SPY2_HUMAN
Alternative names:
-
Alternative UPACC:
O43597; B2R9J9; Q5T6Z7
Background:
Protein sprouty homolog 2 plays a pivotal role in cellular processes by acting as an antagonist of fibroblast growth factor (FGF) pathways. This inhibition is crucial for modulating various developmental processes, including retinal lens fiber differentiation, limb bud outgrowth, and respiratory organogenesis. Additionally, it plays a role in inhibiting TGFB-induced epithelial-to-mesenchymal transition in retinal lens epithelial cells and prevents CBL/C-CBL-mediated EGFR ubiquitination, highlighting its significance in cellular signaling pathways.
Therapeutic significance:
Given its involvement in IgA nephropathy 3, a condition characterized by renal insufficiency progressing to end-stage renal disease, Protein sprouty homolog 2 is a target of interest for therapeutic intervention. Understanding its function and the genetic variants affecting it opens doors to developing strategies aimed at mitigating disease progression and improving patient outcomes.