Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We use our state-of-the-art dedicated workflow for designing focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
O43734
UPID:
CIKS_HUMAN
Alternative names:
Adapter protein CIKS; Connection to IKK and SAPK/JNK; E3 ubiquitin-protein ligase CIKS; Nuclear factor NF-kappa-B activator 1; TRAF3-interacting protein 2
Alternative UPACC:
O43734; B2RAY9; E1P555; Q5R3A3; Q7Z6Q1; Q7Z6Q2; Q7Z6Q3; Q9H5W2; Q9H6Y3; Q9NS14; Q9UG72
Background:
E3 ubiquitin ligase TRAF3IP2, also known as Adapter protein CIKS and Nuclear factor NF-kappa-B activator 1, plays a pivotal role in immune response regulation. It catalyzes 'Lys-63'-linked polyubiquitination, enhancing protein-protein interactions and cell signaling. This protein is a crucial adapter in IL17A-mediated signaling, interacting with IL17RA and IL17RC, leading to activation of NF-kappa-B and MAPkinase pathways.
Therapeutic significance:
TRAF3IP2's involvement in diseases like Psoriasis 13 and familial Candidiasis 8 highlights its potential as a therapeutic target. Understanding its role could pave the way for innovative treatments for these chronic inflammatory conditions.