Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
O43809
UPID:
CPSF5_HUMAN
Alternative names:
Cleavage and polyadenylation specificity factor 25 kDa subunit; Cleavage factor Im complex 25 kDa subunit; Nucleoside diphosphate-linked moiety X motif 21; Nudix hydrolase 21; Pre-mRNA cleavage factor Im 68 kDa subunit
Alternative UPACC:
O43809; Q6IB85; Q6NE84
Background:
The Cleavage and polyadenylation specificity factor subunit 5, also known as NUDT21, plays a pivotal role in mRNA processing. It is a component of the cleavage factor Im (CFIm) complex, crucial for pre-mRNA 3'-end cleavage and polyadenylation, essential steps in the maturation of pre-mRNA into functional mRNAs. NUDT21 is involved in the recruitment of multiprotein complexes to specific sequences on pre-mRNA, influencing alternative cleavage and polyadenylation (APA) and thereby affecting mRNA 3'-end formation. Its ability to bind to 5'-UGUA-3' elements upstream of polyadenylation signals enhances pre-mRNA 3'-end processing.
Therapeutic significance:
Understanding the role of Cleavage and polyadenylation specificity factor subunit 5 could open doors to potential therapeutic strategies.