Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
O43913
UPID:
ORC5_HUMAN
Alternative names:
-
Alternative UPACC:
O43913; A4D0P8; O60590; O95268
Background:
Origin recognition complex subunit 5 plays a pivotal role in DNA replication initiation. As a component of the origin recognition complex (ORC), it is essential for binding origins of replication in an ATP-dependent manner. Despite the lack of identified specific DNA sequences that define origins of replication, ORC's function in assembling the pre-replication complex underscores its significance in cellular biology.
Therapeutic significance:
Understanding the role of Origin recognition complex subunit 5 could open doors to potential therapeutic strategies. Its fundamental involvement in DNA replication initiation presents a unique opportunity for developing novel interventions in diseases where this process is dysregulated.