Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We employ our advanced, specialised process to create targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The procedure entails thorough molecular simulations of the catalytic and allosteric binding pockets, accompanied by ensemble virtual screening that factors in their conformational flexibility. When developing modulators, the structural modifications brought about by reaction intermediates are factored in to optimize activity and selectivity.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
O60313
UPID:
OPA1_HUMAN
Alternative names:
Optic atrophy protein 1
Alternative UPACC:
O60313; D3DNW4; E5KLJ5; E5KLJ6; E5KLJ7; E5KLK1; E5KLK2
Background:
Dynamin-like 120 kDa protein, mitochondrial, also known as Optic atrophy protein 1, plays a pivotal role in maintaining mitochondrial morphology through the regulation of mitochondrial fusion and fission. It binds to lipid membranes, promoting membrane tubulation, and is involved in mitochondrial genome maintenance. Its activity is crucial for the balance between mitochondrial dynamics and the structural integrity of the mitochondrial network.
Therapeutic significance:
Optic atrophy protein 1 is implicated in several diseases, including Optic atrophy 1, Dominant optic atrophy plus syndrome, Behr syndrome, and Mitochondrial DNA depletion syndrome 14. These conditions highlight the protein's critical role in visual function and neurological health. Understanding its mechanisms opens avenues for targeted therapies in mitochondrial and neurodegenerative diseases.