AI-ACCELERATED DRUG DISCOVERY

Small ribosomal subunit protein uS14m

Explore its Potential with AI-Driven Innovation
Predicted by Alphafold

Small ribosomal subunit protein uS14m - Focused Library Design

Available from Reaxense

This protein is integrated into the Receptor.AI ecosystem as a prospective target with high therapeutic potential. We performed a comprehensive characterization of Small ribosomal subunit protein uS14m including:

1. LLM-powered literature research

Our custom-tailored LLM extracted and formalized all relevant information about the protein from a large set of structured and unstructured data sources and stored it in the form of a Knowledge Graph. This comprehensive analysis allowed us to gain insight into Small ribosomal subunit protein uS14m therapeutic significance, existing small molecule ligands, relevant off-targets, and protein-protein interactions.

 Fig. 1. Preliminary target research workflow

2. AI-Driven Conformational Ensemble Generation

Starting from the initial protein structure, we employed advanced AI algorithms to predict alternative functional states of Small ribosomal subunit protein uS14m, including large-scale conformational changes along "soft" collective coordinates. Through molecular simulations with AI-enhanced sampling and trajectory clustering, we explored the broad conformational space of the protein and identified its representative structures. Utilizing diffusion-based AI models and active learning AutoML, we generated a statistically robust ensemble of equilibrium protein conformations that capture the receptor's full dynamic behavior, providing a robust foundation for accurate structure-based drug design.

 Fig. 2. AI-powered molecular dynamics simulations workflow

3. Binding pockets identification and characterization

We employed the AI-based pocket prediction module to discover orthosteric, allosteric, hidden, and cryptic binding pockets on the protein’s surface. Our technique integrates the LLM-driven literature search and structure-aware ensemble-based pocket detection algorithm that utilizes previously established protein dynamics. Tentative pockets are then subject to AI scoring and ranking with simultaneous detection of false positives. In the final step, the AI model assesses the druggability of each pocket enabling a comprehensive selection of the most promising pockets for further targeting.

 Fig. 3. AI-based binding pocket detection workflow

4. AI-Powered Virtual Screening

Our ecosystem is equipped to perform AI-driven virtual screening on Small ribosomal subunit protein uS14m. With access to a vast chemical space and cutting-edge AI docking algorithms, we can rapidly and reliably predict the most promising, novel, diverse, potent, and safe small molecule ligands of Small ribosomal subunit protein uS14m. This approach allows us to achieve an excellent hit rate and to identify compounds ready for advanced lead discovery and optimization.

 Fig. 4. The screening workflow of Receptor.AI

Receptor.AI, in partnership with Reaxense, developed a next-generation technology for on-demand focused library design to enable extensive target exploration.

The focused library for Small ribosomal subunit protein uS14m includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.

Small ribosomal subunit protein uS14m

partner:

Reaxense

upacc:

O60783

UPID:

RT14_HUMAN

Alternative names:

28S ribosomal protein S14, mitochondrial

Alternative UPACC:

O60783; Q5R358

Background:

The Small ribosomal subunit protein uS14m, also known as 28S ribosomal protein S14, mitochondrial, plays a crucial role in the mitochondrial ribosome. Its primary function involves participating in the synthesis of proteins within mitochondria, essential for cellular energy production and metabolic processes.

Therapeutic significance:

Given its association with Combined oxidative phosphorylation deficiency 38, a disorder marked by mitochondrial dysfunction, understanding the role of Small ribosomal subunit protein uS14m could open doors to potential therapeutic strategies. Targeting this protein may offer avenues for treating the underlying mitochondrial abnormalities in affected individuals.

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