AI-ACCELERATED DRUG DISCOVERY

Focused On-demand Library for Guanylate cyclase soluble subunit beta-2

Available from Reaxense
Predicted by Alphafold

Focused On-demand Libraries - Reaxense Collaboration

Explore the Potential with AI-Driven Innovation

The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.

We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.

The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.

We employ our advanced, specialised process to create targeted libraries for enzymes.

 Fig. 1. The sreening workflow of Receptor.AI

It includes comprehensive molecular simulations of the catalytic and allosteric binding pockets and the ensemble virtual screening accounting for their conformational mobility. In the case of designing modulators, the structural changes induced by reaction intermediates are taken into account to leverage activity and selectivity.

Several key aspects differentiate our library:

  • Receptor.AI compiles an all-encompassing dataset on the target protein, including historical experiments, literature data, known ligands, and structural insights, maximising the chances of prioritising the most pertinent compounds.
  • The platform employs state-of-the-art molecular simulations to identify potential binding sites, ensuring the focused library is primed for discovering allosteric inhibitors and binders of concealed pockets.
  • Over 50 customisable AI models, thoroughly evaluated in various drug discovery endeavours and research projects, make Receptor.AI both efficient and accurate. This technology is integral to the development of our focused libraries.
  • In addition to generating focused libraries, Receptor.AI offers a full range of services and solutions for every step of preclinical drug discovery, with a pricing model based on success, thereby reducing risk and promoting joint project success.

partner

Reaxense

upacc

O75343

UPID:

GCYB2_HUMAN

Alternative names:

-

Alternative UPACC:

O75343; Q9NZ64

Background:

Guanylate cyclase soluble subunit beta-2 plays a pivotal role in intracellular signaling pathways. This enzyme is crucial for the conversion of GTP to cyclic GMP, a secondary messenger involved in vasodilation, platelet aggregation, and neurotransmission. Its precise mechanism and structure offer a fascinating area for biochemical research.

Therapeutic significance:

Understanding the role of Guanylate cyclase soluble subunit beta-2 could open doors to potential therapeutic strategies. Its involvement in key physiological processes suggests that modulating its activity could offer new avenues for treating cardiovascular diseases and neurological disorders.

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