Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our high-tech, dedicated method is applied to construct targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The procedure entails thorough molecular simulations of the catalytic and allosteric binding pockets, accompanied by ensemble virtual screening that factors in their conformational flexibility. When developing modulators, the structural modifications brought about by reaction intermediates are factored in to optimize activity and selectivity.
Key features that set our library apart include:
partner
Reaxense
upacc
O75452
UPID:
RDH16_HUMAN
Alternative names:
Human epidermal retinol dehydrogenase; Microsomal NAD(+)-dependent retinol dehydrogenase 4; Short chain dehydrogenase/reductase family 9C member 8; Sterol/retinol dehydrogenase
Alternative UPACC:
O75452; Q9UNV2
Background:
Retinol dehydrogenase 16 (RDH16) is a pivotal enzyme in the metabolism of retinol, converting various forms of retinol into their corresponding aldehydes. It exhibits a preference for NAD and demonstrates higher activity with CRBP-bound retinol than with free retinol. RDH16 is also capable of oxidizing 3-alpha-hydroxysteroids, including the conversion of androstanediol and androsterone into dihydrotestosterone and androstanedione, showcasing its versatility in steroid metabolism.
Therapeutic significance:
Understanding the role of Retinol dehydrogenase 16 could open doors to potential therapeutic strategies. Its involvement in retinol and steroid metabolism positions it as a key target for modulating physiological processes related to vision, cellular growth, and hormone regulation.