Focused On-demand Library for Leucine-rich repeat-containing G-protein coupled receptor 5

Focused On-demand Libraries - Reaxense Collaboration

Explore the Potential with AI-Driven Innovation

The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.

We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.

The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.

We employ our advanced, specialised process to create targeted libraries.

Fig. 1. The sreening workflow of Receptor.AI

Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.

Key features that set our library apart include:

The Receptor.AI platform integrates extensive information about the target protein, such as historical experiments, academic research, known ligands, and structural insights, thereby increasing the likelihood of identifying highly relevant compounds.
The platform’s sophisticated molecular simulations are designed to discover potential binding sites, ensuring that our focused library is optimal for the discovery of allosteric inhibitors and binders for cryptic pockets.
With over 50 customisable AI models, verified through extensive testing in commercial drug discovery and research, Receptor.AI is efficient, reliable, and precise. These models are essential in the production of our focused libraries.
Receptor.AI not only produces focused libraries but also provides full services and solutions at every stage of preclinical drug discovery, with a success-based pricing structure that aligns our interests with the success of your project.

partner

Reaxense

upacc

O75473

UPID:

LGR5_HUMAN

Alternative names:

G-protein coupled receptor 49; G-protein coupled receptor 67; G-protein coupled receptor HG38

Alternative UPACC:

O75473; D8MCT0; Q4VAM0; Q4VAM2; Q9UP75

Background:

Leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5) serves as a receptor for R-spondins, enhancing the canonical Wnt signaling pathway. It is a pivotal stem cell marker in the intestinal epithelium and hair follicle. LGR5 facilitates the association with phosphorylated LRP6 and frizzled receptors activated by Wnt, augmenting gene expression. Unlike typical G-protein coupled receptors, LGR5 does not engage heterotrimeric G-proteins for signal transduction.

Therapeutic significance:

Understanding the role of Leucine-rich repeat-containing G-protein coupled receptor 5 could open doors to potential therapeutic strategies.