Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
O75787
UPID:
RENR_HUMAN
Alternative names:
ATPase H(+)-transporting lysosomal accessory protein 2; ATPase H(+)-transporting lysosomal-interacting protein 2; ER-localized type I transmembrane adapter; Embryonic liver differentiation factor 10; N14F; Renin/prorenin receptor; Vacuolar ATP synthase membrane sector-associated protein M8-9
Alternative UPACC:
O75787; B7Z9I3; Q5QTQ7; Q6T7F5; Q8NBP3; Q8NG15; Q96FV6; Q96LB5; Q9H2P8; Q9UG89
Background:
The Renin receptor, also known as ATPase H(+)-transporting lysosomal accessory protein 2, plays a pivotal role in various physiological processes. It functions as a renin and prorenin cellular receptor, contributing to the renin-angiotensin system (RAS) and affecting blood pressure and electrolyte balance. Additionally, it is involved in the assembly of the lysosomal proton-transporting V-type ATPase, crucial for endo-lysosomal acidification and protein degradation.
Therapeutic significance:
The Renin receptor is implicated in Intellectual developmental disorder, X-linked, syndromic, Hedera type, Parkinsonism with spasticity, X-linked, and Congenital disorder of glycosylation 2R. These associations highlight its potential as a target for therapeutic intervention in neurological and metabolic disorders.