Focused On-demand Library for Calcium and integrin-binding family member 2

Available from Reaxense
Predicted by Alphafold

Focused On-demand Libraries - Reaxense Collaboration

Explore the Potential with AI-Driven Innovation

Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.

We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.

Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.

We use our state-of-the-art dedicated workflow for designing focused libraries.

 Fig. 1. The sreening workflow of Receptor.AI

Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.

Our library is unique due to several crucial aspects:

  • Receptor.AI compiles all relevant data on the target protein, such as past experimental results, literature findings, known ligands, and structural data, thereby enhancing the likelihood of focusing on the most significant compounds.
  • By utilizing advanced molecular simulations, the platform is adept at locating potential binding sites, rendering the compounds in the focused library well-suited for unearthing allosteric inhibitors and binders for hidden pockets.
  • The platform is supported by more than 50 highly specialized AI models, all of which have been rigorously tested and validated in diverse drug discovery and research programs. Its design emphasizes efficiency, reliability, and accuracy, crucial for producing focused libraries.
  • Receptor.AI extends beyond just creating focused libraries; it offers a complete spectrum of services and solutions during the preclinical drug discovery phase, with a success-dependent pricing strategy that reduces risk and fosters shared success in the project.







Alternative names:

Kinase-interacting protein 2

Alternative UPACC:

O75838; B4DDF0; H0YM71; Q05BT6


Calcium and integrin-binding family member 2 (CIB2), also known as Kinase-interacting protein 2, plays a pivotal role in intracellular calcium homeostasis and is essential for hearing. It functions as an auxiliary subunit of the sensory mechanoelectrical transduction (MET) channel in hair cells, regulating the distribution of TMC1 and TMC2 proteins and the MET channel's function in auditory hair cells. CIB2 is crucial for the maintenance and survival of cochlear hair cells and photoreceptor cell function.

Therapeutic significance:

CIB2's involvement in severe to profound sensorineural hearing loss (DFNB48) and Usher syndrome 1J, characterized by congenital deafness and retinitis pigmentosa, underscores its therapeutic significance. Understanding the role of CIB2 could open doors to potential therapeutic strategies for these auditory and visual impairments.

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