Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We use our state-of-the-art dedicated workflow for designing focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
O75884
UPID:
RBBP9_HUMAN
Alternative names:
B5T-overexpressed gene protein; Retinoblastoma-binding protein 10; Retinoblastoma-binding protein 9
Alternative UPACC:
O75884; D3DW31; Q5JPH9; Q9H1D8
Background:
Serine hydrolase RBBP9, also known as Retinoblastoma-binding protein 9, plays a crucial role in cellular processes. Its substrates remain unidentified, yet it is known to negatively regulate TGF-beta signaling, impacting SMAD2-SMAD3 phosphorylation. This protein's interaction with RB1 and displacement of E2F1 suggests a significant role in cellular transformation and resistance to TGF-beta's growth-inhibitory effects.
Therapeutic significance:
Understanding the role of Serine hydrolase RBBP9 could open doors to potential therapeutic strategies. Its involvement in key signaling pathways and cellular transformation processes highlights its potential as a target for drug discovery, aiming to modulate TGF-beta signaling in disease contexts.