Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We use our state-of-the-art dedicated workflow for designing focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Several key aspects differentiate our library:
partner
Reaxense
upacc
O75951
UPID:
LYZL6_HUMAN
Alternative names:
-
Alternative UPACC:
O75951; Q6UW30
Background:
Lysozyme-like protein 6 plays a crucial role in reproductive biology, facilitating sperm-egg plasma membrane adhesion and fusion during fertilization. This protein also exhibits bacteriolytic activity, effectively combating Micrococcus luteus and Staphylococcus aureus. Its activity is notably pH-dependent, peaking at around pH 5.6, and demonstrates a selective efficacy against Gram-positive bacteria under physiological conditions.
Therapeutic significance:
Understanding the role of Lysozyme-like protein 6 could open doors to potential therapeutic strategies. Its unique bacteriolytic function and involvement in fertilization highlight its potential as a target for developing treatments against bacterial infections and reproductive health issues.