Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
O94759
UPID:
TRPM2_HUMAN
Alternative names:
Estrogen-responsive element-associated gene 1 protein; Long transient receptor potential channel 2; Transient receptor potential channel 7; Transient receptor potential melastatin 2
Alternative UPACC:
O94759; D3DSL6; Q5KTC2; Q6J3P5; Q96KN6; Q96Q93
Background:
Transient receptor potential cation channel subfamily M member 2 (TRPM2) is a versatile protein implicated in various cellular processes. It functions as a nonselective, voltage-independent cation channel, facilitating Na(+) and Ca(2+) influx, thereby increasing cytoplasmic Ca(2+) levels. TRPM2 is activated by ADP-ribose, moderate heat, and oxidative stress, playing a crucial role in signaling via intracellular Ca(2+) levels, insulin secretion, and immune responses.
Therapeutic significance:
Understanding the role of Transient receptor potential cation channel subfamily M member 2 could open doors to potential therapeutic strategies. Its involvement in Ca(2+) homeostasis and response to cellular stress highlights its potential as a target in treating diseases linked to calcium dysregulation and oxidative stress.