Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
O94973
UPID:
AP2A2_HUMAN
Alternative names:
100 kDa coated vesicle protein C; Adaptor protein complex AP-2 subunit alpha-2; Adaptor-related protein complex 2 subunit alpha-2; Alpha-adaptin C; Alpha2-adaptin; Clathrin assembly protein complex 2 alpha-C large chain; Huntingtin yeast partner J; Huntingtin-interacting protein 9; Huntingtin-interacting protein J; Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit
Alternative UPACC:
O94973; O75403; Q53ET1; Q96SI8
Background:
AP-2 complex subunit alpha-2 plays a pivotal role in clathrin-dependent endocytosis, facilitating cargo selection and vesicle formation. It acts as a cargo receptor for membrane proteins involved in receptor-mediated endocytosis and is crucial for synaptic vesicle membrane recycling. The protein recognizes specific endocytosis signal motifs, contributing to efficient cargo sorting. Its interaction with polyphosphoinositide-containing lipids positions AP-2 on the membrane, where it serves as a platform for accessory proteins.
Therapeutic significance:
Understanding the role of AP-2 complex subunit alpha-2 could open doors to potential therapeutic strategies.