Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
O94979
UPID:
SC31A_HUMAN
Alternative names:
ABP125; ABP130; SEC31-like protein 1; SEC31-related protein A; Web1-like protein
Alternative UPACC:
O94979; B4DIW6; B7ZKZ7; B7ZL00; H7C2W3; Q17RR5; Q5H9P6; Q5XG74; Q659G7; Q6ZU90; Q7LCX9; Q86TJ0; Q8IZH4; Q9P048; Q9P0A6; Q9UM05; Q9UM06
Background:
Protein transport protein Sec31A, known by alternative names such as ABP125 and SEC31-like protein 1, plays a crucial role in cellular logistics. It is a component of the COPII complex, essential for forming transport vesicles from the endoplasmic reticulum, facilitating the physical deformation of membranes into vesicles and selecting cargo molecules for transport.
Therapeutic significance:
Given its involvement in Halperin-Birk syndrome, a neurodevelopmental disorder with severe outcomes, understanding the role of Protein transport protein Sec31A could open doors to potential therapeutic strategies. Its pivotal role in vesicle formation and cargo selection makes it a promising target for addressing the underlying cellular malfunctions in this syndrome.