Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The procedure entails thorough molecular simulations of the catalytic and allosteric binding pockets, accompanied by ensemble virtual screening that factors in their conformational flexibility. When developing modulators, the structural modifications brought about by reaction intermediates are factored in to optimize activity and selectivity.
Key features that set our library apart include:
partner
Reaxense
upacc
O95251
UPID:
KAT7_HUMAN
Alternative names:
Histone acetyltransferase binding to ORC1; Lysine acetyltransferase 7; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2
Alternative UPACC:
O95251; B3KN74; B4DF85; B4DFB4; B4DFE0; B4DGY4; E7ER15; G5E9K7
Background:
Histone acetyltransferase KAT7, also known as Lysine acetyltransferase 7, plays a pivotal role in acetylating histone H3 at 'Lys-14' and histone H4 at multiple lysine residues. This acetylation is crucial for various biological processes including gene transcription, DNA replication initiation, and embryonic development. KAT7's specificity is modulated by its association with different scaffold subunits, directing its activity towards specific histone marks.
Therapeutic significance:
Understanding the role of Histone acetyltransferase KAT7 could open doors to potential therapeutic strategies. Its involvement in the maintenance of leukemia stem cells in acute myeloid leukemia (AML) by facilitating the expression of key genes highlights its potential as a target for therapeutic intervention in leukemia.