Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The method includes detailed molecular simulations of the catalytic and allosteric binding pockets, along with ensemble virtual screening that considers their conformational flexibility. In the design of modulators, structural changes induced by reaction intermediates are taken into account to enhance activity and selectivity.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
O95365
UPID:
ZBT7A_HUMAN
Alternative names:
Factor binding IST protein 1; Factor that binds to inducer of short transcripts protein 1; HIV-1 1st-binding protein 1; Leukemia/lymphoma-related factor; POZ and Krueppel erythroid myeloid ontogenic factor; TTF-I-interacting peptide 21; Zinc finger protein 857A
Alternative UPACC:
O95365; D6W619; O00456; Q14D41; Q5XG86
Background:
Zinc finger and BTB domain-containing protein 7A, known by alternative names such as Factor binding IST protein 1 and Leukemia/lymphoma-related factor, plays a pivotal role in gene transcription regulation. It represses a wide range of genes involved in cell proliferation, differentiation, and the TGF-beta signaling pathway. This protein binds specifically to a consensus sequence, influencing chromatin organization and the recruitment of transcription factors to gene regulatory regions.
Therapeutic significance:
The protein is linked to Macrocephaly, neurodevelopmental delay, lymphoid hyperplasia, and persistent fetal hemoglobin, a disease characterized by adenoid overgrowth and sleep apnea. Understanding the role of Zinc finger and BTB domain-containing protein 7A could open doors to potential therapeutic strategies for this condition and its related abnormalities in intellectual development and hemoglobin production.