Focused On-demand Library for Pantetheine hydrolase VNN2

Available from Reaxense
Predicted by Alphafold

Focused On-demand Libraries - Reaxense Collaboration

Explore the Potential with AI-Driven Innovation

This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.

We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.

The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.

Our top-notch dedicated system is used to design specialised libraries for enzymes.

 Fig. 1. The sreening workflow of Receptor.AI

This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.

Key features that set our library apart include:

  • The Receptor.AI platform integrates extensive information about the target protein, such as historical experiments, academic research, known ligands, and structural insights, thereby increasing the likelihood of identifying highly relevant compounds.
  • The platform’s sophisticated molecular simulations are designed to discover potential binding sites, ensuring that our focused library is optimal for the discovery of allosteric inhibitors and binders for cryptic pockets.
  • With over 50 customisable AI models, verified through extensive testing in commercial drug discovery and research, Receptor.AI is efficient, reliable, and precise. These models are essential in the production of our focused libraries.
  • Receptor.AI not only produces focused libraries but also provides full services and solutions at every stage of preclinical drug discovery, with a success-based pricing structure that aligns our interests with the success of your project.







Alternative names:

Glycosylphosphatidyl inositol-anchored protein GPI-80; Protein FOAP-4; Vascular non-inflammatory molecule 2

Alternative UPACC:

O95498; A0AUZ3; A6NDY1; A8K4E3; A8K7W0; B2DFZ0; B2DFZ1; B2DFZ2; B2DFZ3; F6XL73; Q2XUN1; Q9UJF3; Q9UMW2


Pantetheine hydrolase VNN2, also known as Glycosylphosphatidyl inositol-anchored protein GPI-80, Protein FOAP-4, and Vascular non-inflammatory molecule 2, plays a crucial role in the hydrolysis of carboamide linkages in D-pantetheine. This process recycles pantothenic acid (vitamin B5) and releases cysteamine, contributing to vital biological functions such as thymus homing of bone marrow cells and regulation of beta-2 integrin-mediated cell adhesion, migration, and motility of neutrophil.

Therapeutic significance:

Understanding the role of Pantetheine hydrolase VNN2 could open doors to potential therapeutic strategies.

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