Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
O95863
UPID:
SNAI1_HUMAN
Alternative names:
Protein snail homolog 1
Alternative UPACC:
O95863; B2R842; Q9P113; Q9UBP7; Q9UHH7
Background:
Zinc finger protein SNAI1, also known as Protein snail homolog 1, plays a pivotal role in the epithelial to mesenchymal transition (EMT), crucial for embryonic development, cell migration, and survival. It regulates gene expression by binding to specific promoter regions and interacting with histone demethylase complexes, thereby influencing chromatin structure and gene transcription. Its involvement in repressing E-cadherin and other genes through histone modification highlights its significance in cellular processes.
Therapeutic significance:
Understanding the role of Zinc finger protein SNAI1 could open doors to potential therapeutic strategies. Its central role in EMT and gene regulation presents it as a target for interventions in diseases where these processes are dysregulated.